Bioperine is a manufactured and patented piperine extract. It is a bioactive component of black pepper that is rich in antioxidant and anti-inflammatory properties. Bioperine is also known as black pepper extract.

BIOPERINE®

BIOPERINE - GENERAL INFORMATION

• In general, we might think that the higher the dose of nutrients we take, the more our body will utilize them. But biologically speaking, this is not always true. Some nutrients given in higher doses can actually negate the benefits and will not be absorbed by the body.
• Similarly, if someone believes that since Bioperine® comes from black pepper, all they have to do is increase their consumption of black pepper. Unfortunately, direct increase in black pepper consumption will not help achieve increased nutrient absorption.
• According to clinical research, Bioperine® should be in the "right place at the right time" in the digestive tract, and even during illness, Bioperine® will have better absorption of nutrients. In addition, if piperine were to remain in its unchanged form of raw black pepper, it would take the body a long time to convert it into the appropriate form. Therefore, purified piperine extract is necessary to achieve increased absorption.

Bioperine® has been clinically tested on several groups of nutrients and both fat-soluble and water-soluble vitamins, which showed significant increase in bioavailability by increasing the absorption of nutrients. Herbal extracts were also better absorbed when combined with Bioperine®.

Individual substances will represent their respective group in terms of their properties. Here are some of the studies highlighting the increased bioavailability.

BIOAVAILABILITY

In pharmacology, bioavailability refers to the portion of a given therapeutic substance that enters the general circulation from a given dose and the rate at which this substance is absorbed.

BIOPERINE® – patents

http://www.bioperine.com/index.php/patent

 

Curcumin

A clinical study conducted at St. John Medical College in Bangalore, India, and published in the journal Planta Medica in 1997 under the title "Clinical evidence of the role of Piperine in increasing the bioavailability of Curcumin" became one of the most downloaded articles in this journal.

Bioperine® significantly improves the uptake of curcumin from turmeric extract. Clinical studies have confirmed its effectiveness in a wide range of health conditions in the fight against cancer.

The bioavailability of curcumin (2000 mg), when administered together with Bioperine® (20 mg), was increased by 20 times or 2000% compared to the bioavailability of curcumin without bioperine. The achieved result is free of undesirable side effects.

Iron

In vivo studies were conducted to determine and approve the bioavailability of elemental iron (BioIron) with or without Bioperine®.

A single oral dose of BioIron with Bioperine® (group I) or BioIron without Bioperine® (group II) was tested and blood samples were taken at various time points.

The results indicate that at 8-hour intervals, the serum iron concentration was significantly higher in the group treated with BioIron containing Bioperine® (36.55 ± 9.97 ng/ml) compared to the group treated with BioIron without Bioperine®.

 

β-CAROTENE

In a cross-over study, a small amount of Bioperine® (5 mg) in combination with a formula containing 15 mg of beta-carotene, administered as a dietary supplement once daily, resulted in nearly a 2-fold increase in β-carotene concentration.

In the experimental phase (β-carotene + Bioperine®), there was a 60% increase in the area under the curve compared to the control after 14 days of supplementation.

Resveratrol
Preclinical studies

In vivo studies conducted by the University of Wisconsin, USA showed that Bioperine® significantly improved the bioavailability of resveratrol by 229%, and the maximum serum concentration (Cmax) was increased by 1544%.

Clinical studies

Sixteen healthy, young, adult participants took part in a study that investigated the effect of resveratrol and piperine in combination with physical training.

Volunteers received pills containing placebo or resveratrol (500 mg) + Bioperine® (10 mg) in combination for 4 weeks. All participants performed 3 sessions of submaximal endurance training of the wrist flexor muscles (non-dominant arm) weekly. The opposite arm served as a control.

The results suggest that the combination group showed significant changes compared to baseline values in mitochondrial capacity for post-tests (40% increase) (Δk = 0.58, p = 0.001), as well as compared to placebo (p <0.05) at 4 weeks.

Overall, supplementation with resveratrol and Bioperine® in combination may be helpful in enhancing skeletal forearm muscle mitochondrial potential during low-intensity physical training.

Selenium

In a double-blind study, the bioavailability of selenium was assessed individually and in combination with Bioperine®. The serum selenium level was approximately 30% higher in the group receiving selenium with Bioperine® after 2 weeks of treatment. In subsequent time points, the serum selenium level was within the normal range in both groups.

Vitamin B6

The bioavailability of vitamin B6 (100 mg) was assessed without Bioperine®. After 2 hours, the maximum serum concentration of vitamin B6 was 2.5 times higher in the group receiving Bioperine® compared to the control group. After 4 hours, the level of vitamin B6 in the Bioperine® group was 1.4 times higher than in the control group.

Coenzyme Q10

Initially, the bioavailability of coenzyme Q10 (CoQ10) was evaluated without Bioperine® supplementation in a double-blind clinical trial. Then, 21 days after simultaneous administration with Bioperine®, it resulted in an absolute increase of CoQ10 in the serum by 1.12 ng/mL compared to an absolute increase of 0.85 ng/mL in the control group.